RNA Details
Disease Name
hepatic ischemia injury
Tissue
liver
RNA Symbol
mir-34a
RNA ID
RNA Type
miRNA
Alteration Pattern
nf kb acetylation
Species
mus musculus
Detection Methods
dual-lucimmunofluorescenceerase reporter assay; qRT-PCR; etc.
Target
P65; P53
Pathway
SIRT1
PubMed ID
Title
Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway
Year
2015
Function
"The increased acetylation of intracellular hmgb1 in saha treated hscs, and this increasing is most likely to be responsible for saha induced down-regulation of nuclear factor kappa b1 (nf-kb1) and is one of the main underlying mechanisms for the therapeutic effect of saha for liver fibrosis."